Neurobiology of Disease Copper-Dependent Inhibition of Human Cytochrome c Oxidase by a Dimeric Conformer of Amyloid-
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چکیده
Peter J. Crouch,1 Rachel Blake,1 James A. Duce,1 Giuseppe D. Ciccotosto,2,3 Qiao-Xin Li,2,3 Kevin J. Barnham,2,3 Cyril C. Curtain,2,3,4 Robert A. Cherny,2,3 Roberto Cappai,2,3 Thomas Dyrks,5 Colin L. Masters,1,2,3 and Ian A. Trounce1 1Centre for Neuroscience and 2Department of Pathology, The University of Melbourne, Victoria 3010, Australia, 3Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia, 4School of Physics and Materials Engineering, Monash University, Clayton, Victoria 3168, Australia, and 5Diagnostics and Radiopharmacy Research, Schering AG, D-13342 Berlin, Germany
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Minocycline blocks c-terminal fragments of amyloid precursor protein-induced neurotoxicity by inhibition of cytochrome c release and caspase-12 activation
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تاریخ انتشار 2005